Placebo-controlled evaluation of a bioengineered, cocaine-metabolizing fusion protein, TV-1380 (AlbuBChE), in the treatment of cocaine dependence.

•A placebo-controlled phase 2 study of TV-1380 in cocaine dependence is described.•TV-1380 is a recombinant protein that metabolizes and inactivates cocaine.•A significant increase in abstinence was not observed at the end of 12-wk treatment.•A dose-dependent increase in the percentage of cocaine-free urines was observed.