脂质体鬼臼毒素混悬液在大鼠表皮及真皮的分布规律初探
Chinese Journal of Dermatology(2003)
Abstract
目的探讨脂质体鬼臼毒素在大鼠皮肤各层的分布规律.方法观察组大鼠涂抹0.5%脂质体鬼臼毒素混悬液,对照组涂抹0.5%鬼臼毒素酊剂,分别在涂药1、2、4、6、12及24 h取皮肤标本,常规石蜡切片,采用激光共聚焦显微成像仪(CLSM)扫描,观察单位面积鬼臼毒素的荧光量.结果鬼臼毒素24 h荧光值曲线下面积(AUC),表皮层中观察组是对照组的1.5倍,真皮层中是2.3倍;对照组在涂药2 h后,表皮和真皮的荧光量即达到峰值(分别为1 585.52/μm2和2 005.66/μm2),在4 h后荧光量迅速降低;而观察组在4 h前,表皮和真皮中的荧光量较低,6 h后逐渐增高,在12 h达峰值(分别为(750.28/μm2和J 073.08/μm2).结论脂质体制剂使鬼臼毒素在皮肤中缓慢释放,并持续较长时间.
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Key words
epidermal distribution,suspen-sion
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