Clinical analysis of 83 cases of invasive squamous cell carcinoma of the vulva

Objective To analyze the clinical manifestations of squamous cell carcinoma of the vulva, and summarize treatment methods to evaluate the efficacy and prognosis. Method 83 cases of vulvar squamous cell carcinoma were followed up at least 1 year were analyzed retrospectively. Result In the 83 cases,patients with preexisting dermatoses accounted for 95. 2%; 60 cases( 72. 3%) were in stageⅠ and Ⅱ,and 23 cases( 27. 7%) were in stage Ⅲ and Ⅳ; The average age of onset was 56. 2 years,and there were 55 post-menopausal cases( 66. 3%); 78 cases had surgery,5 cases received simple radiochemotherapy,and surgery type included: local excision( 10 /78,12. 8%),simple vulvectomy( 4 /78,5. 1%),radical local excision( 37 /78,47. 5%),and radical vulvectomy( 27 /78,34. 6%); There were 51 cases( 65. 4%) with unilateral or bilateral superficial or deep inguinal-femoral lymphadenectomy,and 34 cases with adjuvant radiochemotherapy,including 1 case that had preoperative radiotherapy. 65 cases( 78. 3%) were in complete remission,and 18 cases( 21. 7%) developed progression,while 11 patients( 16. 9%) relapsed. Overall 5-year response rate was 68. 7%( 57 /83). Patients with positive margin or positive close margin received postoperative adjuvant radiotherapy still had relatively high recurrence( 27. 8%). And patients with tumor invasion over 5 mm or over-dermis involvement had high recurrence of 34. 6%. Of the 11 cases of relapsed patients,1 had surgery,1 received radiotherapy,and other 9 cases were treated with surgery + radiotherapy or chemotherapy,while 4 cases progressed,7 cases in remission,but in which 4 cases experienced repeated recurrence within 5 years. Conclusion Early stage of squamous cell carcinoma of the vulva is in the majority,and the primary procedure is surgery,as the efficacy of postoperative radiotherapy is to be determined. The stage of the disease is correlated with efficacy,the patients with positive surgical margin or deep invasion had a higher recurrence rate,and overall efficacy in relapsed cases is poor.