5-氟尿嘧啶羧甲基壳聚糖微球体的制备及体外释放
Journal of Fujian Medical University(2004)
Abstract
目的探讨羧甲基壳聚糖包药微球体的制备及体外释药特性.方法采用乳化交联法制备5-氟尿嘧啶羧甲基壳聚糖(FU-CMCS)微球体;用红外光谱(IR)对其结构进行表征,扫描电子显微镜(SEM)观察微球体形貌及表面结构,利用激光粒度分布仪考察微球体的粒径分布;考察包药微球体在人工胃液、人工肠液、人工结肠液汉中的释放.结果电镜扫描显示微球体表面结构规整、致密,FU-CMCS微球体粒径60%在2~15 μm,药物含量为8.39%.体外释放实验表明,包药微球体在pH 1.22、pH 7.01、pH 7.45缓冲溶液中均具有缓释作用.结论FU-CMCS微球体在体外具有缓释作用.
MoreTranslated text
Key words
Tumor Microenvironment
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined