Research on mechanism of COPD caused by plasma homocysteine and NO
Journal of Clinical Pulmonary Medicine(2014)
Abstract
Objective To study the significance of homocysteine( Hcy),nitric oxide( NO),nitric oxide synthase( NOS) and high sensitive C reactive protein( hs-CRP) in the mechanism of AECOPD patients. Methods The levels of plasma Hcy,NO,NOS,hs- CRP were determined in 54 patients with AECOPD and 60 healthy controls. Results The levels of tHcy and hs- CRP were significantly higher,and the levels of NO and NOS were significantly lower in the observation group than in the control group( P 0. 01). Hcy was negatively correlated with NO and NOS( r =- 0. 57,- 0. 49),and positively correlated with hs-CRP( r = 0. 48)( P 0. 01). Conclusion There exists a low level of NO and a high level of Hcy in plasma of COPD patients,which take part in oxidative stress and inflammatory reaction in COPD and increase the development of COPD disease.
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