Effect of pulsed electromagnetic fields produced by different frequencies on bone metabolism markers in osteoprotegerin gene knock-out mice
Chinese Journal of Osteoporosis(2013)
摘要
Objective To explore the optimal frequency of pulsed electromagnetic fields for the treatment of osteoporosis,by using different frequencies of pulsed electromagnetic fields to treat osteoprotegerin(OPG) knock-out mouse model Methods Fifteen male and fifteen female 8-week OPG knock-out mice were randomly divided into 3 groups: Group A,Group B,and Group C.Each group had 10 mice.Group A was blank control group with no intervention.Mice in Group B received PEMFs treatment at 8 Hz frequency with 4.0 mT intensity,20 min per day,for 30 days.Mice in Group C received PEMFs treatment at 32 Hz frequency with 4.0 mT intensity,20 min per day,for 30 days.Tartrate-resistant acid phosphatase 5b and serum bone γ carboxyglutamic acid of all rats in each group were measured using ELISA before the treatment and 30 days after the treatment.Results The concentrations of tartrate-resistant acid phosphatase 5b and serum bone γ carboxyglutamic acid in Group B and C after the treatment were significantly different with those in Group A(P0.05).Whereas the bone metabolism markers in Group B before or after the treatment had no significant difference compared with those in Group C(P0.05).Conclusion The treatment of pulsed electromagnetic fields for osteoprotegerin gene knock-out mice is really effective.Both the frequency of 8 HZ and 32 HZ can produce the same therapeutic effect.
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关键词
Osteoprotegerin
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