Hypogonadotropic hypogonadism in women: treatment options

Treatment of female hypogonadotropic hypogonadism is geared to mimic normal physiology, allowing for age appropriate development, while preventing complications secondary to sex hormone deprivation. In this paper we review data concerning efficacy and safety of sex hormone replacement therapy at the various stages of female reproduction, taking into account safety profiles of different types of estrogen and progesterone formulations, and their interactions with other components of the pituitary substitutive therapy.