Upregulation of FosB/ΔFosB in limbic circuits after tooth exodontia-induced occlusal instability in an experimental model of unpredictable chronic stress

Glauce Crivelaro Nascimento,Bruna Balbino de Paula,Daniele P. Ferrari,Daniela Mizusaki Iyomasa,Yamba C.L. Pereira,João F. Pedrazzi,Mariza Bortolanza,Ana Carolina Issy,João Paulo Mardegan Issa,Christie R.A. Leite-Panissi,Mamie Mizusaki Iyomasa,Elaine Del-Bel

Brain Research Bulletin（2021）

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摘要

•Diazepam prevents FosB/ΔFosB+ upregulation in the limbic areas after exodontia and UCS.•Occlusion dental alteration increases intranuclear neuron activation in CeA, PVN and dPAG regions.•Occlusion alteration model by unilateral exodontia promotes anxiety-like behavior similarly to UCS.

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关键词

EPM,BSA,CFA,CeA,CRH,DAB,dPAG,Dzp,Exo,GABA,HPA,NAc,OF,PAG,PVN,TMD,UCS

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