Evaluation of accuracy of cervical biopsy in diagnosing CIN I

Objective To evaluate the accuracy of cervical biopsy under the guidance of colposcopy in diagnosing cervical intraepithelial neoplasia grade Ⅰ(CIN Ⅰ). Methods Clinical and pathological data from 235 patients with CIN Ⅰ diagnosed by biopsy under the guidance of colposcopy were retrospectively analyzed,who were given cervical loop electrosurgical excision procedure(LEEP). Results Of 235 cases,the diagnosis of biopsy was accordant with that of final pathology in 152 cases(64.7%),over-diagnosed in 29 cases(12.3%),deficient diagnosed in 46 cases(19.6%),and 8 cases was finally diagnosed as cervical invasive cancer with the missing diagnosis rate of 3.4%. Conclusion In case of cytology results of atypical high-grade squamous intraepithelial lesion(ASC-H) or high-grade squamous intraepithelial lesions(HSIL),or unsatisfactory colposcopy,a diagnosis of CIN Ⅰ by biopsy under the guidance of colposcopy may not be reliable and the vigilance should be taken to avoid missing diagnosis.