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美沙酮与丁丙诺啡联合梯度递减治疗海洛因依赖者疗效观察

肖国椿,肖李莉,赖朝东,黎力勋

HEBEI MEDICAL JOURNAL（2001）

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Abstract
目的对比研究美沙酮和丁丙诺啡联合梯度递减疗法与单纯丁丙诺啡梯度递减疗法治疗海洛因依赖的临床效果.方法对1444例海洛因依赖者采用10 d递减疗法进行戒毒治疗,随机分为两组,A组:1 028例,联合应用美沙酮与丁丙诺啡治疗;B组:416例,应用丁丙诺啡治疗.结果治疗后两组轻、中、重度积分均明显降低,治疗前5 d A组比B组戒断症状积分要低得多,A组治疗期间戒断症状控制平稳,效果确切,总体临床脱瘾率为96.89%,与单用丁丙诺啡治疗脱瘾率94.71%比,差异显著(P＜0.05).结论美沙酮与丁丙诺啡联合梯度治疗海洛因依赖的替代递减疗法联用合理安全,效果好,递减迅速,副作用轻微,值得临床推荐应用.
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methadone hydrochloride,buprenorphine hydrochloride,heroin addicts,ordinary dosage
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