Design and synthesis of 5-cyclopropyl substituted cyclic acylguanidine compounds as BACE1 inhibitors
Chinese Chemical Letters(2016)
摘要
Replacing one of the phenyl rings of the lead compound 1 with cyclopropyl results in compounds with much improved inhibition efficiency, the diphenyl fragment at the P3 position and the substituents at the second phenyl ring also contribute significantly to the bioactivity improvement.
更多查看译文
关键词
Alzheimer's disease,BACE1 inhibitor,β-Secretase,Drug discovery,Cyclic acylguanidine
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要