胃癌根治术中腹腔热化疗对血流动力学的影响
Chinese Journal of Pathophysiology（2003）
Abstract
目的:观察胃癌根治手术中进行腹腔热化疗对血流动力学的影响.方法:择期年龄31-75岁胃癌根治手术病人26例,在手术切除癌肿准备关腹前行低渗腹腔热化疗.记录热化疗前和热化疗过程中血流动力学指标并分析.结果:心率(HR)显著增快,至化疗结束后又显著减慢.过程中平均动脉压(MAP)显著下降,结束后恢复到热灌洗前水平.总外周阻力指数(SVRI)由(1 830±362)降至(1 340±270)dyn·s·cm-5·m-2,平均肺动脉压(MPAP)、肺动脉楔压(PAWP)均较热化疗前显著增高,化疗结束即恢复正常.结论:热化疗可引起体温上升及继发一系列血流动力学变化.
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Key words
hyperthermic peritoneal chemiotherapy,gastric cancer,radical resection,hemodynamics
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