Relationship between Insulin Resistance and Plasma Fibrinogen in Adult with Simple Obesity

Objective To explore the relationships of plasma fibrinogen( FIB) with insulin resistance( IR) and blood lipid levels in adults with simple obesity. Methods Seventy- eight adults with simple obesity treated in our hospital between September 2012 and March 2013 were included in this study,which were divided into three groups according to the body mass index( BMI),including Class I obesity group( n = 34),Class II obesity group( n = 30),and Class III obesity group( n = 14).And 35 adults with simple overweight and 67 healthy adults visiting our hospital during the same period were enrolled as the control groups. The height,weight,waistline,hip circumference,fasting blood glucose( FBG) level,fasting insulin( FIN) level,blood lipid levels,and FIB level were tested,and the body mass index( BMI),waist- to- hip ratio( WHR),and IR index( HOMA- IR) were calculated. Results With the increase of BMI,the levels of FIB,HOMA- IR,FBG,FIN,triglyceride( TG),cholesterol( TC),low density lipoprotein- cholesterol( LDL- C) increased gradually,while the level of high density lipoprotein- cholesterol( HDL- C) decreased gradually. FIB was significantly positively correlated with BMI,WRH,FBG,FIN,HOMA- IR,TC,TG,and LDL- C( P 0. 01),and negatively correlated with HDL- C( P 0. 01). Multiple stepwise regression analyses indicated that BMI and TG were the independent risk factors of FIB; and FIB,BMI,FBG,FIN,and LDL- C were the independent risk factors of HOMA- IR. Conclusion The levels of IR and blood lipids are abnormal in adult with simple obesity,which might be due to the overexpression of FIB.