胃黏膜上皮及胃癌细胞中错配修复基因hMLH1蛋白的表达及意义
Journal of Dalian Medical University(2004)
Abstract
[目的]探讨hMLH1蛋白作为胃癌预警标记物的可能性.[方法] 免疫组织化学SP法半定量检测24例非肿瘤患者胃黏膜上皮、39例胃癌患者癌旁黏膜上皮及癌细胞hMLH1蛋白的表达情况,比较该蛋白在不同黏膜上皮组织中表达的差异性.[结果] hMLH1蛋白表达率在非肿瘤患者胃黏膜上皮为33%,明显低于胃癌患者癌旁黏膜上皮的72%(P=0.003)及癌细胞的74%(P=0.001),但在癌旁黏膜上皮与癌细胞间无显著性差异(P=0.799).[结论] hMLH1蛋白在胃癌患者癌旁黏膜上皮及癌细胞的表达强于非肿瘤患者胃黏膜上皮表达的现象,提示其作为胃癌预警组织学标记物的可能性.
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Key words
hmlh1 protein,gastric cancer,gastric epithelia
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