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硫酸镁治疗实验动物缺氧性肺动脉高压

张伟利,单海燕,李笑宏,林建海

Shanghai Medical Journal（2002）

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Abstract
目的探讨硫酸镁治疗新生儿持续肺动脉高压(PPHN)的疗效.方法用7只实验小猪吸入低浓度氧气造成急性缺氧性肺动脉高压模型来模拟PPHN.通过颈外静脉插入心导管,经右心室进入肺动脉检测肺动脉压力(PAP)和心输出量等.通过股动脉插管检测体循环血压.同时测心率、血氧饱和度、血气分析和血镁浓度.结果实验小猪缺氧10 min后肺动脉收缩压(SPAP)升高(42.1±19.4)%(P＜0.01),舒张压(DPAP)和平均肺动脉压(MPAP)分别升高(46.8±23.9)%和(39.7±22.1)%(P＜0.01).滴注硫酸镁后SPAP下降(25.2±5 4)%(P＜0.01),DPAP和MPAP分别下降(25.5±6.3)%和(22.5±5.3)%(P＜0.01).体循环收缩压无明显改变.血镁浓度明显升高.结论硫酸镁能显著降低肺动脉高压,对体循环血压影响小.
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Key words
hypoxic pulmonary hypertension,magnesium,pulmonary hypertension
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