播散性浅表光线性汗孔角化病致病基因的定位
Chinese Journal of Dermatology（2003）
Abstract
目的对播散性浅表光线性汗孔角化病(DSAP)的致病基因进行定位.方法收集一个DSAP家系成员的血样抽提基因组DNA,选用12号染色体长臂上已知致病区域的7个微卫星标记进行基因扫描,并用LJNKAGE软件(5.1 Version)对基因分型结果进行连锁分析.结果连锁分析结果发现本家系在微卫星标记D12S79的两点最大LOD值为5.15(θ=0.00).结论DSAP致病基因位于12号染色体的长臂上.
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Key words
genetic locus
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