苯丙氨酸解氨酶脂质体的制备及其抗白血病细胞增殖作用的初探
Cancer Research on Prevention and Treatment（2003）
Abstract
目的探讨苯丙氨酸解氨酶(PAL)脂质体对小鼠白血病L1210细胞和人白血病K562细胞生长的抑制作用. 方法采用改良的逆相蒸发法制备出PAL脂质体,应用MTT还原法分别检测PAL脂质体和游离的PAL对L1210和K562细胞增殖的作用.结果在酶活性相同条件下,PAL脂质体比游离PAL有较强的抑制细胞增殖作用,对K562细胞作用48h, IC50分别为0.905U/ml和1.140U/ml, 对L1210细胞作用48h, IC50分别为0.958U/ml和1.513U/ml.结论 PAL脂质体能抑制L1210和K562白血病细胞增殖,并呈时间和剂量依赖关系(P<0.01).
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Key words
liposome,cytotoxic activity,ammonia-lyase
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