Therapeutic effect of 0.02% fluorometholone combined with sodium hyaluronate on patients with moderate dry eye disease

Objective To investigate the clinical effect of 0. 02% fluorometholone combined with sodium hyaluronate in the treatment of patients with moderate dry eye disease. Methods Forty-one patients( 41 eyes) diagnosed as moderate dry eye disease in Shanghai EENT Hospital from June 2012 to October 2012 were divided into 2 groups randomly. The patients of group A were treated with 0. 02% fluorometholone eye drops combined with sodium hyaluronate eye drops,and the patients of group B were treated with sodium hyaluronate eye drops only. All the patients were evaluated with OSDI scores,conjunctival hyperemia scores,corneal fluorescein staining scores,break-up time( BUT),Schirmer and meibomian gland secretion scores at three time points: before treatment,14 days and 28 days after treatment. Results OSDI scores,conjunctival hyperemia scores,corneal fluorescein staining scores,BUT,Schirmer and meibomian gland secretion scores had significant improvements in all patients after 28-day treatment( P 0. 05). Conjunctival hyperemia scores and meibomian gland secretion scores improved significantly in group A than those in group B( P 0. 05). Conclusions Fluorometholone combined with sodium hyaluronate can relieve conjunctival hyperemia and improve meibomian gland function.( Chin J Ophthalmol and Otorhinolaryngol,2014,14: 100-103)