芍药苷改善睡眠作用机制研究
The Chinese Journal of Clinical Pharmacology(2015)
Abstract
目的:研究四逆散冻干粉主要化学成分芍药苷改善睡眠的作用机制。方法取Wistar大鼠平分为4组(每组10只):正常组、四逆散冻干粉组、白芍冻干粉组、芍药苷组。称取冻干粉20 g,加水溶解配成0.5 kg? L-1溶液,灌胃给药,正常组给予等体积蒸馏水。每天1次,连续7 d。用HPLC方法测定大鼠血清和脑脊液中移行成分。结果给予四逆散冻干粉主要化学成分芍药苷后,脑脊液中内源性物质峰面积约是空白脑脊液峰面积的12.5倍,表明芍药苷能明显促进脑脊液中内源性物质的分泌,从而达到改善睡眠作用,该内源性物质最终确定为5-羟色胺。结论四逆散冻干粉主要化学成分芍药苷是通过促进脑脊液中内源性物质5-羟色胺的分泌达到改善睡眠作用。
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