Expression and Significance of Cyclin E,P21WAF1 in Gastric Carcinoma

Objective:To investigate the funtion of Cyclin E,P21WAF1 in genesis and prognosis of gastric carcinoma by the examination of Cyclin E,P21WAF1 ,and their expression and the relationship with clinical - pathological indexes . Methods: A total of 78 paraffin - embedded tissue specimens of gastric carcinomas and 35 peri - carcinomatous gastric tissues were observed by the use of S -P method to examine the expression of cyclin E,P21wAf1. Results: The positive expression rate of Cyclin E,P21WAF1 were dramatically higher in the tumors than in the peri - carcinomatous tissues( P 0. 05). The expresson of Cyclin E was related to the differentiation of gastric carcinoma ,the higher the postive expression rate of CyclinE( P 0. 005 ) ,the lower the degree of the differentiation. The positive rate of P21WAF1 was higher in the group with nolymph nodes metastasis than in the group with lymph nodes metastasis (P 0. 05) . Conclusion: It revealed that Cyclin E,P21WAF1were correlated with the genesis and progression of gastric carcinoma.