肝毛细线虫虫卵可溶性抗原诱导大鼠保护性免疫的研究
Chinese Journal of Parasitic Disease Control(2003)
Abstract
目的探讨肝毛细线虫虫卵可溶性抗原(SEA)诱导保护性免疫的效果.方法30只SD大鼠随机分为Ⅰ、Ⅱ、Ⅲ 3组,每组10只.Ⅰ组和Ⅱ组分别予以0.1 ml00 μg/0.1 ml和200 μg/0.1 ml SEA加等量的弗氏完全佐剂(FCA)每周腹腔注射免疫大鼠1次;Ⅲ组为对照组,每周腹腔注射0.1 ml生理盐水加等量的FCA,共3次.各组末次免疫1周后,用约500粒/鼠肝毛细线虫感染期虫卵感染大鼠,攻击感染4周后,剖杀大鼠检获虫卵,计算每克肝卵(LEPG)及减卵率,并检测大鼠血清特异性抗体IgG和血液嗜酸性粒细胞含量.结果400 μg和200 μg免疫原组减卵率分别是50.7%和24.9%,两免疫组LEPG、抗体水平及血液嗜酸性粒细胞含量均高于对照组(P<0.01).结论肝毛细线虫SEA可诱导大鼠产生保护性免疫.
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Key words
protective immunity,antigen,infection
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