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培美曲塞联合顺铂治疗晚期肺腺癌的疗效

Jiangsu Medical Journal(2013)

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Abstract
目的 探讨培美曲塞联合顺铂(PC方案)一线治疗晚期肺腺癌的疗效.方法 初治晚期肺腺癌患者100例均分为两组:A组接受PC方案治疗,B组采用吉西他滨联合顺铂(GP方案)治疗,比较两组的疗效.结果 A组有效率为36.0%、无进展生存时间(PFS)8.9个月和总生存时间(OS) 23.4个月,与B组的32.0%、7.8个月和20.0个月相仿(P>0.05).A组血液学毒性低于B组(P<0.05).结论 PC方案治疗晚期肺腺癌的近期疗效与GP方案相似,可作为一线治疗方案;但PC方案的血液学毒性发生率较低.
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