Advances in the synthesis of 2,4,5-trifluorophenylacetic acid

Chemical Research and Application（2014）

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摘要

2,4,5-Trifluorophenylacetic acid is a key intermediate to the dipeptidyl peptidase( DPP)-IV inhibitor anti-diabetic drug sitagliptin. This review summarized and commented on the synthetic methods of 2,4,5-trifluorophenylacetic acid.

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synthesis,acid

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