Advance in conotoxin MVIIA reaserch

The conotoxins from Conus is a kind of peptides with peculiar pharmacological properties.They have been optimized through50million years evolution to target specific ion channels and receptors with high affinities and selectivities.Theω-conotoxin MⅦA from Conus magus is a specific and selective blocker of N-type voltage-sensi-tive calcium channels.Preclinical and clinical studies have shown that MⅦA possesses both analgesic and neuropro-tective properties.Reseach advance in physicochemical,pharmacological,preclinical and clinica properties of MⅦA was reviewed in this article.