18F-FDG PET/CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系
Chinese Journal of Medical Imaging Technology(2014)
Abstract
目的 探索结直肠癌(CRC) PET/CT显像总病灶糖酵解(TLG)与其淋巴管密度(LVD)和血管内皮细胞生长因子-C(VEGF-C)的关系.方法 回顾分析36例病理证实的CRC患者(淋巴结转移组19例,无淋巴结转移组17例)的术前PET/CT资料,记录最大标准摄取值(SUVmax)和TLG.以免疫组化分析肿瘤和正常黏膜葡萄糖转运蛋白-1 (GLUT-1)和VEGF-C的表达,D2-40标记淋巴管,记数LVD,分析其与SUVmax及TLG的关系.结果 CRC组织VEGF-C和GLUT-1阳性表达率显著高于正常黏膜(P均<0.01).淋巴结转移组的SUVmax、TLG、LVD和VEGF-C显著高于无淋巴结转移组(SUVmax:t=3.602,P=0.001;TLG:t=3.421,P=0.002;LVD:t=3.051,P=0.004; VEGF-C:x2=8.047,P=0.045).SUVmax与TLG、TLG与LVD、TLG与GLUT-1的累积光密度(IOD)值存在直线相关关系(r=0.607、0.654、0.367,P均<0.05).VEGF-C不同表达等级间TLG和LVD差异有统计学意义(F=5.922、35.579,P均<0.001).GLUT-1与VEGF-C的表达水平呈等级相关(r=0.302,P单侧 =0.028).结论 结直肠癌病灶的TLG与LVD和VEGF-C存在正相关,TLG可在一定程度上反映肿瘤淋巴结转移和淋巴管生成状况.
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Key words
Colorectal neoplasms,Tomography,emission-computed,single-photon,Total lesion glycolysis,Vascular endothelial growth factor C,Neoplasm metastasis
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