Oral care with chlorhexidine for prevention of ventilator associated pneumonia:a meta analysis

Objective:To explore the efficacy of Oral care with chlorhexidine for prevention of ventilator associated pneumonia(VAP).Methods:We searched domestic and international literature,followed by assessing the effect of the chlorhexidine solution on the VAP incidence in a rigorous way one by one.After meta-analysis provided by the Cochrane Collaboration's RevMan 4.2software package,we summed and drew conclusions.Results:9literatures and a total of 1892patients were adopted in the study.931patients in the observation group were treated by chlorhexidine solution,while 961patients in the control group were used placebo,NaHCO3or phenolic mixture or 0.01% KMNO4solution.The results showed that VAP in observation group was 8.49%(79/931),and was 12.28%(118/961)in the other group.Conclusion:Chlorhexidine solution for oral care has a good effect on reducing the incidence of VAP.