The Relation Between The Degree Of Left Ventricular Mass Regression And Serum Potassium Level Change In Patients With Primary Aldosteronism After Adrenalectomy

Background Primary aldosteronism (PA) is one of the major etiologies for secondary hypertension featuring more prominent left ventricular hypertrophy. The purpose of the study was to investigate the predictive factors of left ventricular mass index (LVMI) regression in patients with PA after adrenalectomy.Methods We prospectively analyzed 30 patients with aldosterone-producing adenoma (APA) who received adrenalectomy from October 2006 to September 2008. Echocardiography was performed preoperation and 1 year after operation.Results Thirty patients with aldosterone-producing adenoma undergoing adrenalectomy were enrolled. In a 1-year follow-up, LVMI decreased significantly by an average of 18.6%. Net LVMI decrease (LVMI) was associated with preoperative LVMI, preoperative serum potassium level, baseline systolic blood pressure (SBP), baseline diastolic blood pressure, net SBP decrease (SBP), net diastolic blood pressure decrease, preoperative/postoperative change of log-transformed plasma aldosterone concentration, preoperative/postoperative change of log-transformed plasma renin activity, and preoperative/postoperative change of serum potassium level (serum potassium level). In a multiple regression analysis, preoperative LVMI ( = -0.287, P = 0.049), SBP ( = 0.518, P = 0.01), and serum potassium level ( = -20.471, P = 0.014) were significantly correlated with LVMI.Conclusions The LVMI in patients with PA regressed significantly after adrenalectomy. Preoperative LVMI, SBP, and serum potassium levels are independent factors associated with the degree of LVMI regression.