CD66 and CD49f expressing cells are associated with distinct neoplastic phenotypes and progression in human cervical cancer

European Journal of Cancer(2016)

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摘要
•CD66+ cells are collectively invading tumour cells with CD49f+ cells at the invasive front.•CD66 cells have traits of migration and partial-EMT; and CD49f cells have proliferation traits.•TGFβ1 is associated with migratory CD66 cells.•Metastatic tumours are associated with high TGFβ1, CD66 and CD49f expression.•CD66 and CD49f subsets, contribute differently to local-recurrences and metastasis
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关键词
Cervical cancer,CD66,CD49f,Migration,Tumourigenesis
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