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Heat killed Saccharomyces cerevisiae as an adjuvant for the induction of vaccine-mediated immunity against infection with Mycobacterium tuberculosis.

Ajay Grover,Jennifer McLean,JoLynn Troudt,Chad Foster,Linda Izzo, Elisabeth Creissen, Elisabeth MacDonald,Amber Troy,Angelo Izzo

Vaccine（2016）

Cited 10|Views18
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Abstract
•First studies to demonstrate the effective use of a Mycobacterium tuberculosis antigen expressing recombinant heat-killed yeast vaccine.•The recombinant heat-killed yeast vaccine induced CD4+ and CD8+ T cell immunity.•The recombinant heat-killed yeast can be used to boost BCG induced immunity.
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Key words
Tuberculosis,Recombinant heat killed yeast vaccine,Immune response,Animal models
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