CRP/oxLDL co-incubates impair endothelial functions through CD32, LOX-1, and keratin 1 with dependence on their ratio

Journal of the Taiwan Institute of Chemical Engineers（2016）

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摘要

•Not only the levels of CRP and oxLDL but also their ratio affects the endothelial nitric oxide release.•CD32, LOX-1, and KRT1 mediate the cellular uptake and the effect of CRP/oxLDL complexes on decreasing endothelial nitric oxide release.•KRT1 and LOX-1 have greater co-localization than KRT1 and CD32.

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关键词

Endothelial cells,C-reactive protein (CRP),Oxidized low density lipoprotein (oxLDL),Keratin 1,Nitric oxide (NO)

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