Su1482 Measuring Depth of Invasion From Distal Bile Duct Tumor Can Help Better Predict Prognosis Than the 7th AJCC T-Staging System

female ratio (83.2% vs 62.2%, P<0.01), and more patients were from CS-endemic area (45.3% vs 25.5%, P<0.01) than those without CS infection.However there was no statistically significant difference in Diabetes mellitus, Hepatitis B virus, Body mass index, tumor location, tumor stage, CEA, CA 19-9, and pathologic differentiation.Univariate analysis of prognostic factor showed that tumor location, curative resection, tumor stage, and laboratory test including CEA, CA 19-9, jaundice, serum alkaline phosphatase were significantly associated with overall survival (OS).However, CS infection was not significant factor associated with OS.According to multivariate analysis, CEA < 5ng/ml, curative resection, early tumor stage (AJCC I, II) were identified as independent prognostic factors with the hazard ratios (HR) = 0.462 (95% confidence interval (CI) = 0.318-0.669),HR = 0.482 (CI = 0.337-0.690),and HR = 0.319 (CI = 0.226-0.450),respectively Conclusions: Patients with CS-associated CCA had some different clinical characteristics compared to patients without CS infection; younger at diagnosis for CCA, higher male to female ratio, more prevalent in CS endemic area.However CS infection was not significant factor associated with OS.Further molecular genetic studies as well as clinical study are warranted to understand the CS-associated CCA.