Meta Analysis of Relationship between CYP3A5 Gene Polymorphism and Pharmacokinetics of Sirolimus in Renal Transplant Recipients

Objective To assess the relationship between CYP3A5 gene polymorphism and the dose ratio of blood drug concentration and body weight( C0/ D) of sirolimus in renal transplant recipients. Methods Relevant databases were retrieved to collect information about studies on the correlation between CYP3A5 gene polymorphism and sirolimus C0/ D in renal transplant recipients,Meta software Rev Man5. 3 was used to analyze the effective data of the included literature to get the combined OR and 95% CI. Results A total of 5 articles were included involviong466 patients. Meta analysis results showed that the CYP3A5 * 3 / * 3 genotype sirolimus C0/ D was significantly higher than that in CYP3A5* 1 / * 1 and CYP3A5* 1 / * 3 genotype( P u003c 0. 000 01). Conclusion CYP3A5 gene polymorphism is closely related to the safety and effectiveness of sirolimus in reneal transplantation patients. Individual administration should be based on CYP3A5 genotype.