Podoplanin (D2-40) and Clusterin Are Reliable Markers of Normal and Inflamed Synovium

Synovial lining cells (“intima”) arise from a proliferation of fibroblast-like cells and recruitment of macrophage-like cells from the circulation. Recent work has shown that synovial intimal cells are positive for clusterin (CLU) and podoplanin (PP). CLU has been noted to mark nonneoplastic synovium adjacent to tenosynovial tumors, and some studies suggest that PP …