Endotelioand Cardioprotective Effects of HMG-Co-A Reductase in Endotoksininducing Endotelial Dysfunction
Naučnyj rezulʹtat Seriâ Medicina i farmaciâ(2015)
Abstract
The use of inhibitors of HMG-Co-A reductase inhibitor simvastatin, atorvastatin, rosuvastatin and nanoparticulative rosuvastatin on background modeling endotoksininducing pathology, introduction of strain 603 Staphylococcusaureus leads to the development of dose-response endotelioprotectiv action, expressed in the normalization of QED, prevent increase adrenoreactivity and exhaustion of myocardial reserve and and normalization of biochemical markers of inflammation (C-reactive protein) and the level of proinflammatory cytokines. When this is detected positive dynamics and-products of NO and expression of eNOS.
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Key words
дисфункция эндотелия,ингибиторы гмг-ко-а-редуктазы симвастатин,аторвастатин,розувастатин,эндотоксин,endothelial dysfunction,hmg-co-a-reductase inhibitor simvastatin,atorvastatin,rosuvastatin,endotoxin
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