POTENT ANTISENSE OLIGONUCLEOTIDES TO APO(A) NORMALIZE PLASMA LP(A) LEVELS IN THE MAJORITY OF PEOPLE WITH ELEVATED LP(A): RESULTS OF ISIS-APO(A)RX PHASE 2 AND ISIS-APO(A)-LRX PHASE 1 TRIALS
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY(2016)
Abstract
Elevated Lp(a) levels are causal, independent predictors of CVD and aortic stenosis (AS). Specific therapies to potently lower Lp(a) are lacking. We assessed the safety and efficacy of ISIS-APO(a)Rx in patients with elevated Lp(a) and of ISIS-APO(a)-LRx, an optimized antisense oligonucleotide (ASO)
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Key words
oligonucleotides,isis-apo,isis-apo
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