Assuring The Proper Analytical Performance Of Measurement Procedures For Immunosuppressive Drug Concentrations In Clinical Practice: Recommendations Of The International Association Of Therapeutic Drug Monitoring And Clinical Toxicology Immunosuppressive Drug Scientific Committee

THERAPEUTIC DRUG MONITORING(2016)

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摘要
Monitoring immunosuppressive drugs (ISDs) in blood or plasma is still a key therapeutic drug monitoring (TDM) application in clinical settings. Narrow target ranges and severe side effects at drug underexposure or overexposure make accurate and precise measurements a must. This overview prepared by the Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology is intended to serve as a summary and guidance document describing the current state-of-the-art in the TDM of ISDs.
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关键词
TDM,immunosuppressant drugs,cyclosporine,tacrolimus,sirolimus,everolimus,mycophenolic acid,LC-MS/MS,immunoassay,design,validation,verification
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