Formulation, Characterization and Evaluation of Gastro-RetentiveFloating Tablets of Norfloxacin

The purpose of the research work was to develop gastro-retentive drug delivery system of Norfloxacin. Floating tablets were prepared by wet granulation method using sodium bicarbonate and citric acid anhydrous, like Hydroxypropyl Methylcellulose (HPMC K100M), Xanthum gum, and Microcrystalline Cellulose (MCC). Norfloxacin floating tablets prepared were found to be good without chipping, capping and sticking. The drug content was found to be uniform in all the tablet formulations. Formulation F3 and F5 showed desired drug release and thus selected as the best formulation. Finally optimized formulation F3 and F5 complying with all properties of floating tablets were found to be satisfactory in all aspects.