Analysis of the Clinical Treatment of Pulmonary Thromboembolism in Two Medical Centers

SESSION TITLE: Pulmonary Vascular Disease: VTE SESSION TYPE: Original Investigation Poster PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM PURPOSE: To improve treatment and prognosis of pulmonary thromboembolism (PTE) through retrospective analysis of the medical treatment and clinical outcomes METHODS: Clinical data of 510 consecutive cases of PTE hospitalized at Shanghai Pulmonary Hospital and Tongji Hospital from January 1, 2004 to December 31, 2013 were retrospectively reviewed. The patients were divided into three groups based on different treatment, including anticoagulation alone group (n=418), systemic thrombolysis group (n=47) and catheter-directed therapy group (n=45). Then we analyzed and compared therapeutic effect, bleeding complication and recurrence of three groups respectively. RESULTS: The total efficacy rates of anticoagulation group, thrombolysis group and catheter-directed therapy group were 77.5%, 78.7% and 77.7%. Meanwhile the survival rates of them were 91.9%, 87.2% and 91.1%, respectively. There was no diference in overall efficacy and survival rates among these three methods (P>0.05). The hemorrhage rates of anticoagulation group, thrombolysis group and catheter-directed therapy group were 3.8%, 12.8%, and 11.1%. Furthermore, one patient died of cerebral hemorrhage in thrombolysis group, the hemorrhage rate of this group was higher than that of anticoagulation group, and the difference was statistically significant (P<0.05). For patients discharged, after 6-month follow-up and 12-month follow-up, the recurrence rate of anticoagulation group was higher than that of thrombolysis group and catheter-directed therapy group, respectively, but there was no statistically significant difference (P>0.05). CONCLUSIONS: Prompt treatment for PTE could improve clinical outcomes and reduce the risk of recurrence. For the best PTE prognosis, it is important to take the optimal treatment based on the patient’s clinical characteristics and risk stratification. CLINICAL IMPLICATIONS: The cliniacl research shows it is important to take the optimal treatment based on the patient’s clinical characteristics and risk stratification. DISCLOSURE: The following authors have nothing to disclose: Kebin Cheng, Haoming Song, Jinfu Xu, Lemin Wang, Jinming Liu, Beilan Gao No Product/Research Disclosure Information