Quercetin-3-O-rhamnoside from Euphorbia hirta protects against snake Venom induced toxicity.

Kadiyala Gopi,K. Anbarasu,Kadali Renu,S. Jayanthi,Bannikuppe S. Vishwanath,Gurunathan Jayaraman

Biochimica et Biophysica Acta (BBA) - General Subjects（2016）

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摘要

•The fractions of Euphorbia hirta methanolic extract were evaluated against Naja naja venom enzymes.•One of the active fractions inhibited multiple enzymes of Naja naja venom in vitro.•The active principle was identified as Quercetin-3-O-rhamnoside (QR).•Hemorrhage and edema causing activity of venom was also inhibited by QR ex vivo.•Further, its mode of enzyme inhibition was compared with its aglycon Quercetin against PLA2 activity in silico.

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关键词

Euphorbia hirta,Snake venom,Naja naja,Quercetin-3-O-rhamnoside,PLA2

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