S&T-50 DOES TRANSPERINEAL PROSTATE BIOPSY REDUCE COMPLICATIONS COMPARED WITH TRANSRECTAL BIOPSY? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS

You have accessJournal of UrologyScience & Technology Posters1 Apr 2016S&T-50 DOES TRANSPERINEAL PROSTATE BIOPSY REDUCE COMPLICATIONS COMPARED WITH TRANSRECTAL BIOPSY? A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMISED CONTROLLED TRIALS Cindy Garcia, Matthew Winter, Philip Bergersen, Henry Woo, and Venu Chalasani Cindy GarciaCindy Garcia More articles by this author , Matthew WinterMatthew Winter More articles by this author , Philip BergersenPhilip Bergersen More articles by this author , Henry WooHenry Woo More articles by this author , and Venu ChalasaniVenu Chalasani More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2879AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The detection of prostate cancer relies in part upon the two established techniques of transperineal (TP) and transrectal (TR) prostate biopsy. The more commonly used TR biopsy is associated with higher rates of infective complications, as it traverses the rectum. This systematic review and meta-analysis aims to determine if any difference in complication rate exists between TR and TP prostate biopsy. METHODS We searched the following biomedical databases: Medline, Embase, and Cochrane Central Register of Controlled Trials from 1946 to 2015. Conference proceedings of the BAUS, AUA and EAU over the past 10 years were also searched. There were no language restrictions. Only randomised controlled trials comparing TR to TP prostate biopsy were considered for inclusion. A meta-analysis was performed using a fixed effects model. Summary risk ratio (RR) and its 95% confidence interval were calculated. A RR of less than 1 favoured fewer complications with TR prostate biopsy, whilst a RR of greater than 1 indicated more complications with TR prostate biopsy. RESULTS Six studies were identified with 619 patients undergoing TR prostate biopsy and 634 undergoing TP prostate biopsy. No significant heterogeneity was noted between trials. Reported complications were haematuria (75 TR and 79 TP; RR 0.96 [0.72 - 1.28]), infectious complications (21 TR and 11 TP; RR 2.18 [1.06 - 4.47]), urinary retention (9 TR and 4 TP; RR 2.08 [0.68 - 6.31]), rectal bleeding (34 TR and 5 TP; RR 5.19 [2.43 - 11.11]), haematospermia (2 TR and 5 TP; RR 0.55 [0.11 - 2.75]) and vasovagal events (6 TR and 3 TP; RR 2.00 [0.50 - 7.95]). No statistically significant difference was seen between complication rates of TR and TP with regard to haematuria, vasovagal events, haematospermia, and urinary retention. The TR approach was associated with more infectious complications and rectal bleeding, compared to TP prostate biopsy; these results were statistically significant. CONCLUSIONS A statistically significant increase in infectious complications and rectal bleeding was seen in the TR approach. No statistically significant difference in haematuria, urinary retention, vasovagal events or haematospermia was found between TP and TR prostate biopsy. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e328-e329 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Cindy Garcia More articles by this author Matthew Winter More articles by this author Philip Bergersen More articles by this author Henry Woo More articles by this author Venu Chalasani More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...