Morphological control of tranilast attached to carrier particles by amino acid addition

Takuro Nishimura,Kazunori Kadota,Ayaka Kunita, Yohei Nakayama,Hideaki Tagishi,Yuichi Tozuka

Advanced Powder Technology（2016）

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摘要

•Tranilast SDPs without additives appeared as rod-like crystals.•Histidine acted as an inhibitor of tranilast nucleation in ethanol aqueous solutions.•Tranilast SDPs with histidine formed amorphous or unstable crystals.•Tranilast SDPs with aspartic acid formed stable crystal because of already precipitated.

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关键词

Aspartic acid,Leucine,Histidine,Fluorescence analysis,Crystal form of tranilast

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