Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women

Lise M.A. De Strooper,Viola M.J. Verhoef,Johannes Berkhof,Albertus T. Hesselink, Helena M.E. de Bruin,Folkert J. van Kemenade,Remko P. Bosgraaf,Ruud L.M. Bekkers,Leon F.A.G. Massuger,Willem J. G. Melchers,Renske D.M. Steenbergen,Peter J.F. Snijders,Chris J. L. M. Meijer,Daniëlle A.M. Heideman

Gynecologic Oncology（2016）

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摘要

•FAM19A4/mir124-2 triage of HPV-positive self-samples is a feasible and promising tool•FAM19A4/mir124-2 analysis identifies HPV-positive women at risk of cervical cancer.•FAM19A4/mir124-2 analysis performs equally well in lavage and brush self-samples.•Further validation of HPV self-sampling with FAM19A4/mir124-2 triage is warranted

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关键词

Human papillomavirus,Self-sampling,Reflex test,Cervical cancer,Molecular screening,DNA methylation,HPV16/18 genotyping

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