Structural characterization of low level degradants in aztreonam injection and an innovative approach to aid HPLC method validation

Qingmei Ye,Wei Ding,Frank Rinaldi,Yande Huang,Scott A. Miller,Mark S. Bolgar

Journal of Pharmaceutical and Biomedical Analysis（2016）

引用 7|浏览19

暂无评分

摘要

•The structures of low level degradants in drug product and API are elucidated.•Degradation pathways for the formations of three new degradants are proposed.•The exact concentrations are determined by qNMR for use as HPLC standards.

查看译文

关键词

Aztreonam,Degradants,Identification,Structure elucidation,Quantitative NMR

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要