A carbohydrate-binding affinity ligand for the specific enrichment of glycoproteins

•The ligand is capable of binding glycoproteins under physiological conditions.•The ligand displays affinity to glucose oxidase and interacts with the glycoprotein through its glycan moiety.•Benzoboroxole plays an important role in sugar binding.•The ligand has a preference for sugar alcohols and the furanose form of the monosaccharides tested.•The ligand processes the potential to resolve sialylated and neutral glycoforms.