Ropivacaine vs tetracaine in topical anesthesia for intravitreal injection

Aim: The object of the study was to evaluate the long term efficacy and safety of ropivacaine 0,5% vs tetracaine 0,5% for topicalanesthesia in intravitreal injection of dexamethasone in patients with diabetic macular edema (DME) and anti-vascular endothelial growth factor (VEGF) therapy.Methods: Thirty-seven patients were enrolled in the study. Intravitreal anti-vascular endothelial growth factor (VEGF) andDexamethasone were placed in DME patients.Intravitreal administration determines appropriate and long-lasting drug's concentration without systemic side effects. Topicalanesthesia under ropivacaine 0,5% vs tetracaine 0,5% was performed.Results: Intravitreal injection without any supplemental anesthesia and sedation was realized. Patients reported mild pain(recorded by a 0 to 10 scale) during the procedure with optimal operative result.Conclusions: Topical anesthesia with ropivacaine and tetracaine is safe and effective in intravitreal injection. The long-lastinganesthesia secured low pain during this limited but unpleasant procedure.