Stilbenoids from Hopea acuminata

Two resveratrol oligomers, a dimer (1) and a tetramer (2), were isolated from the ethyl acetate extracts of the leaves of Hopea acuminata along with vaticanol B, vaticaphenol A, vateriaphenol B, hopeaphenol, e-viniferindiol, balanocarpol, and ampelopsin A. The structures of these compounds were established on the basis of spectroscopic data including two-dimentional nuclear magnetic resonance experiments. Compound 2, vaticanol B, vaticaphenol A, vateriaphenol B, hopeaphenol were found to inhibit protein splicing mediated by the Mycobacterium tuberculosis RecA intein in a nonspecific manner.