Synthesis, bioactivity and functional evaluation of linker-modified allatostatin analogs as potential insect growth regulators

A series of AST analogs were synthesized by modifying the linker of K24. The bioassay results showed that all target analogs exhibited different potencies in inhibiting JH biosynthesis and activating Dippu-AstR as a consequence of vary linker length. Analog L6, with the longest linker (n=5), had outstanding effect on inhibiting JH biosynthesis in vitro and in vivo, as well as good activity in inhibiting basal oocyte growth.