A novel PI3K/AKT signaling axis mediates Nectin-4-induced gallbladder cancer cell proliferation, metastasis and tumor growth

Yijian Zhang,Shibo Liu,Lei Wang,Yaoshi Wu,Jiaqi Hao,Zheng Wang,Wei Lu, Xu-An Wang,Fei Zhang, Yang Cao,Haibin Liang,Huai-Feng Li,Yuan-Yuan Ye,Qiang Ma,Shuai Zhao,Yijun Shu,Run-Fa Bao, Lin Jiang,Yunping Hu,Jian Zhou,Lei Chen,Yingbin Liu

Cancer Letters（2016）

引用 73|浏览46

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摘要

•The upregulation of Nectin-4 promotes GBC cell proliferation and metastasis.•Nectin-4 facilitates GBC progression via PI3K/AKT pathway activation of Rac1.•Nectin-4 is potential prognostic factor and therapeutic target in GBC.

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关键词

Nectin-4,Tumor progression,Gallbladder cancer,PI3K/AKT pathway,Rac1

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