Functionalized gold nanoparticles for topical delivery of Methotrexate for the possible treatment of psoriasis

H. A. Bessar,I. Venditti,I. Fratoddi,L. Benassi,C. Vaschieri,E. Botti, F. Mostafa,M. Russo,A. Costanzo,G. Pellacani

Colloids and Surfaces B: Biointerfaces（2015）

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摘要

AuNPs were prepared and loaded with methotrexate (MTX). The bioconjugate was topically used on C57BL/6 mouse normal skin in order to trace the absorption behavior. In vivo tracing on bare rat skin show successful delivery of Methotrexate in the epidermis and in less intensity also in the dermis.

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关键词

Hydrophilic gold nanoparticles,Drug loading,Methotrexate drug delivery,Functionalized nanoparticles

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