Resveratrol provides neuroprotection by inhibiting phosphodiesterases and regulating the cAMP/AMPK/SIRT1 pathway after stroke in rats

Dan Wan,Yehan Zhou,Ke Wang,Yongying Hou, Ruihang Hou,Xiufeng Ye

Brain Research Bulletin（2016）

引用 95|浏览6

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摘要

•Resveratrol alleviates injury following cerebral ischemia/reperfusion.•Resveratrol provides neuroprotection through inhibition of phosphodiesterase 4A, and eventually decreasing ATP consumption.•Phosphodiesterase 4A may be the direct target of resveratrol for treatment of stroke.

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关键词

Resveratrol,Stroke,SIRT1,AMPK,ATP,PDEs

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